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Hk2tm1Laak
Targeted Allele Detail
Nomenclature
Symbol: Hk2tm1Laak
Name: hexokinase 2; targeted mutation 1, Markku Laakso
MGI ID: MGI:3624862
Synonyms: HKII-
Gene: Hk2  Location: Chr6:82725025-82774454 bp, - strand  Genetic Position: Chr6, 35.94 cM
E8.5 Hk2tm1Laak/Hk2tm1Laak embryos are growth retarded

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56644
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin resistance cassette was inserted into exon 4. (J:56644)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hk2 Mutation:  20 strains or lines available
References
Original:  J:56644 Heikkinen S, et al., Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes. J Biol Chem. 1999 Aug 6;274(32):22517-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory