Phenotypes associated with this allele

• Allele Symbol: Hk2^tm1Laak
• Allele Name: targeted mutation 1, Markku Laakso
• Allele ID: MGI:3624862
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hk2^tm1Laak/Hk2^tm1Laak	involves: 129P2/OlaHsd * BALB/c * DBA/2	MGI:3625099
ht2	Hk2^tm1Laak/Hk2^+	involves: 129P2/OlaHsd * BALB/c * DBA/2	MGI:3625100

Genotype
MGI:3625099

hm1

• Allelic Composition: Hk2^tm1Laak/Hk2^tm1Laak
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

E8.5 Hk2^tm1Laak/Hk2^tm1Laak embryos are growth retarded

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:56644 )

• homozygous mutation of Hk2 is embryonic lethal around E8.5

growth/size/body

embryonic growth retardation ( J:56644 )

• at E7.5, ~45% of homozygous embryos are visibly growth retarded and at E8.5, all homozygous embryos are severely growth retarded

embryo

embryonic growth retardation ( J:56644 )

• at E7.5, ~45% of homozygous embryos are visibly growth retarded and at E8.5, all homozygous embryos are severely growth retarded

Genotype
MGI:3625100

ht2

• Allelic Composition: Hk2^tm1Laak/Hk2⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * DBA/2

growth/size/body

decreased body weight ( J:56644 )

• at weaning, heterozygous male mice produced by the first backcross to BALB/c * DBA/2 weigh less than wild-type littermates, but by the third backcross generation, there is no significant weight difference

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus 2	DOID:0110741	OMIM:125852	J:56644