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Hmga1tm1Afus
Targeted Allele Detail
Nomenclature
Symbol: Hmga1tm1Afus
Name: high mobility group AT-hook 1; targeted mutation 1, Alfredo Fusco
MGI ID: MGI:3621126
Gene: Hmga1  Location: Chr17:27556620-27563674 bp, + strand  Genetic Position: Chr17, 14.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106702
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons III through V were replaced with a neomycin resistance cassette. RT-PCR failed to detect transcript from mutant hearts and spleens. (J:106702)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmga1 Mutation:  29 strains or lines available
References
Original:  J:106702 Fedele M, et al., Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice. Cancer Res. 2006 Mar 1;66(5):2536-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory