Phenotypes associated with this allele

• Allele Symbol: Hmga1^tm1Afus
• Allele Name: targeted mutation 1, Alfredo Fusco
• Allele ID: MGI:3621126
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmga1^tm1Afus/Hmga1^tm1Afus	involves: 129S7/SvEvBrd * C57BL/6	MGI:3621547
ht2	Hmga1^tm1Afus/Hmga1^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3621548

Genotype
MGI:3621547

hm1

• Allelic Composition: Hmga1^tm1Afus/Hmga1^tm1Afus
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:106702 )

• myocytes enlarged

cardiac hypertrophy ( J:106702 )

• hypertrophy starts to develop around 2 months of age

• consistently seen at 12 months of age

• heart weight/body weight ratio increased by 77%

• no hypertension seen

heart left ventricle hypertrophy ( J:106702 )

• end diastolic left ventricular diameter increased 42%

• end systolic left ventricular diameter increased 51%

• posterior wall thickness increased 19%

• mass increased 70%

growth/size/body

cardiac hypertrophy ( J:106702 )

• no hypertension seen

• hypertrophy starts to develop around 2 months of age

• consistently seen at 12 months of age

• heart weight/body weight ratio increased by 77%

heart left ventricle hypertrophy ( J:106702 )

• end diastolic left ventricular diameter increased 42%

• end systolic left ventricular diameter increased 51%

• posterior wall thickness increased 19%

• mass increased 70%

decreased body weight ( J:106702 )

• body weight is slightly decreased or normal

enlarged spleen ( J:106702 )

• in 80% of homozygotes over 12 months of age

immune system

enlarged spleen ( J:106702 )

• in 80% of homozygotes over 12 months of age

myeloid hyperplasia ( J:106702 )

• in animals over 12 months of age

lymphoid hyperplasia ( J:106702 )

• in animals over 12 months of age

neoplasm

increased leukemia incidence ( J:106702 )

• myeloid leukemia after 12 months of age

increased B cell derived lymphoma incidence ( J:106702 )

• after 12 months of age

hematopoietic system

enlarged spleen ( J:106702 )

• in 80% of homozygotes over 12 months of age

myeloid hyperplasia ( J:106702 )

• in animals over 12 months of age

muscle

abnormal myocardium layer morphology ( J:106702 )

• myocytes enlarged

heart left ventricle hypertrophy ( J:106702 )

• end diastolic left ventricular diameter increased 42%

• end systolic left ventricular diameter increased 51%

• posterior wall thickness increased 19%

• mass increased 70%

Genotype
MGI:3621548

ht2

• Allelic Composition: Hmga1^tm1Afus/Hmga1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

cardiovascular system

cardiac hypertrophy ( J:106702 )

• no hypertension seen

• heart weight/body weight ratio increased by 35%

immune system

enlarged spleen ( J:106702 )

• in 78% of heterozygotes over 12 months of age

hematopoietic system

enlarged spleen ( J:106702 )

• in 78% of heterozygotes over 12 months of age

growth/size/body

cardiac hypertrophy ( J:106702 )

• no hypertension seen

• heart weight/body weight ratio increased by 35%

enlarged spleen ( J:106702 )

• in 78% of heterozygotes over 12 months of age