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Cdc42tm1Brak
Targeted Allele Detail
Nomenclature
Symbol: Cdc42tm1Brak
Name: cell division cycle 42; targeted mutation 1, Cord Brakebusch
MGI ID: MGI:3619134
Synonyms: Cdc42fl, Cdc42flox
Gene: Cdc42  Location: Chr4:137319696-137357720 bp, - strand  Genetic Position: Chr4, 69.83 cM
Kidney abnormalities in Cdc42tm1Brak/Cdc42tm1Brak Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:105811
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 2 was flanked with loxP sites via homologous recombination. (J:105811)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc42 Mutation:  35 strains or lines available
References
Original:  J:105811 Wu X, et al., Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory