Del(2Hoxd8-Hoxd10)21Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Hoxd8-Hoxd10)21Ddu
• Name: deletion, Chr 2, Denis Duboule 21
• MGI ID: MGI:3616640
• Synonyms: Del21Ddu, Del(i-10)
• Gene: Del(2Hoxd8-Hoxd10)21Ddu Location: Chr2:74522268-74538277 bp Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105255
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(2Hoxd8-Hoxd10)21Ddu involves 6 genes/genome features (Hoxd11, Hoxd10, Gm14396 ...) View all
• Mutation details: Produced by targeted meiotic recombination in a cross between Hoxd^tm5Ddu and Hoxd^tm16Ddu in the presence of Tg(Sycp1-cre)4Min. Hoxd8, Hoxd9, and Hoxd10 are deleted from the Hoxd cluster as well as most of the sequenc between Hoxd4 and Hoxd8. (J:105255)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Hoxd8-Hoxd10)21Ddu Mutation: 0 strains or lines available

References

• Original: J:105255 Tarchini B, et al., Control of Hoxd genes' collinearity during early limb development. Dev Cell. 2006 Jan;10(1):93-103
• All: 2 reference(s)