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S1pr4tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: S1pr4tm1Dgen
Name: sphingosine-1-phosphate receptor 4; targeted mutation 1, Deltagen
MGI ID: MGI:3604550
Gene: S1pr4  Location: Chr10:81497747-81500132 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Mutation
origin
Mutant Cell Line:  3620
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in spleen and lymph nodes, moderate levels in lung, thymus, bone marrow, gallbladder, pituitary gland, uterus and white fat and low levels in brain, cortex, subcortical region, cerebellum, brainstem, olfactory bulb, spinal cord, Harderian glands, heart, liver, kidney, skin, urinary bladder, adrenal gland, salivary gland, skeletal muscle, tongue, stomach, small intestine, large intestine, cecum, testis, epididymis, coagulating gland, prostate gland and ovaries. However, beta-galactosidase expression from this allele is detectable only in testis with strong staining in several spermatogenic cells in the seminiferous tubules of testis.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any S1pr4 Mutation:  8 strains or lines available
Notes
See also, data as provided by Deltagen, Inc.
References
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory