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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		S1pr4tm1Dgen
targeted mutation 1, Deltagen
MGI:3604550
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		S1pr4tm1Dgen/S1pr4tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3606609
ht2
 		S1pr4tm1Dgen/S1pr4+ involves: 129P2/OlaHsd * C57BL/6 MGI:3606610


Genotype
MGI:3606609
hm1
Allelic
Composition		 S1pr4tm1Dgen/S1pr4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr4tm1Dgen mutation (1 available); any S1pr4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:101679 )
• homozygous embryos die between E10.5 and E12.5, with embryos appearing partially resorbed by E10.5




Genotype
MGI:3606610
ht2
Allelic
Composition		 S1pr4tm1Dgen/S1pr4+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S1pr4tm1Dgen mutation (1 available); any S1pr4 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased prepulse inhibition ( J:101679 )
• heterozygous mice had lower average PPI scores when a 120 db startling stimulus was preceded by a 90 db prepulse
• significantly decreased prepulse inhibition when compared with age- and sex-matched wild-type control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory