About   Help   FAQ
Targeted Allele Detail
Symbol: Clca2tm1Dgen
Name: chloride channel accessory 2; targeted mutation 1, Deltagen
MGI ID: MGI:3604504
Gene: Clca2  Location: Chr3:144776024-144805204 bp, - strand  Genetic Position: Chr3, 69.31 cM
Alliance: Clca2tm1Dgen page
Germline Transmission:  Earliest citation of germline transmission: J:101679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in skin, urinary bladder, tongue and uterus, moderate levels in eye, pancreas, thymus, gallbladder, stomach, epididymis, seminal vesicle, prostate gland, ovary and white fat, and low levels in olfactory bulb, Harderian glands, heart, lung, kidney, spleen, lymph nodes, adrenal gland, salivary gland, skeletal muscle, small intestine, large intestine, cecum, testis and coagulating gland. However, beta-galactosidase expression from this allele is detectable in only in epithelium in the urinary bladder, trachea and skin and in tracheal cartilage as well as in a few spermatogenic cells in the testis and stromal cells in the ovary. A small piece of tissue adjacent to the heart also showed staining.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clca2 Mutation:  29 strains or lines available
See also, data as provided by Deltagen, Inc.
Original:  J:101679 Deltagen Inc, NIH initiative supporting placement of Deltagen, Inc. mice into public repositories. MGI Direct Data Submission. 2005;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory