Phenotypes associated with this allele

• Allele Symbol: Clca2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3604504
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clca2^tm1Dgen/Clca2^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3606512

Genotype
MGI:3606512

hm1

• Allelic Composition: Clca2^tm1Dgen/Clca2^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

multifocal hepatic necrosis ( J:101679 )

• observed in one homozygous male

enlarged liver ( J:101679 )

• in homozygous male

increased liver weight ( J:101679 )

• increased liver weight to body weight ratio, in 2 of 3 homozygous females and in all males

abnormal hepatocyte morphology ( J:101679 )

• one homozygous female and all homozygous males had hepatocytic hypertrophy which was characterized by increased amount of granular eosinophilic cytoplasm

• the lesion was predominantly centrilobular in the female and in one male

cellular

multifocal hepatic necrosis ( J:101679 )

• observed in one homozygous male

growth/size/body

enlarged liver ( J:101679 )

• in homozygous male

increased liver weight ( J:101679 )

• increased liver weight to body weight ratio, in 2 of 3 homozygous females and in all males