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Targeted Allele Detail
Symbol: Nod2tm1Flv
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3529594
Synonyms: Nod2-
Gene: Nod2  Location: Chr8:88647315-88688474 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:96035
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP-flanked neo replaced exon 3, encoding the CARD domain and P-loop of the NOD domain. Spleens of mutant animals demonstrated a lack of protein by immunoblot analysis. (J:96035)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  32 strains or lines available
Original:  J:96035 Kobayashi KS, et al., Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005 Feb 4;307(5710):731-4
All:  91 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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