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Fcgrttm1Dcr
Targeted Allele Detail
Summary
Symbol: Fcgrttm1Dcr
Name: Fc fragment of IgG receptor and transporter; targeted mutation 1, Derry C Roopenian
MGI ID: MGI:3511510
Synonyms: FcRn-
Gene: Fcgrt  Location: Chr7:44742417-44753246 bp, - strand  Genetic Position: Chr7, 29.12 cM
Alliance: Fcgrttm1Dcr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94189
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence from exon 1 and part of exon2 was replaced with a PGK-neo cassette. Quantitative PCR of liver cDNA indicated the absence of mRNA. Western blot analysis of neonatal intestinal extracts failed to reveal protein product. (J:94189)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 22 strains available      Cell Lines: 0 lines available
Carrying any Fcgrt Mutation:  55 strains or lines available
References
Original:  J:94189 Roopenian DC, et al., The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol. 2003 Apr 1;170(7):3528-33
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory