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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fcgrttm1Dcr
targeted mutation 1, Derry C Roopenian
MGI:3511510
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fcgrttm1Dcr/Fcgrttm1Dcr B6.129X1-Fcgrttm1Dcr/DcrJ MGI:4441043
hm2
Fcgrttm1Dcr/Fcgrttm1Dcr either: 129 or (involves: 129 * C57BL/6) MGI:3511521
cx3
Albem12Mvw/Albem12Mvw
Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
B6.Cg-Tg(FCGRT)32Dcr Albem12Mvw Fcgrttm1Dcr/MvwJ MGI:5608908
cx4
Fcgrttm1Dcr/Fcgrttm1Dcr
X/Yaa
BXSB.129X1-Fcgrttm1Dcr/Dcr MGI:6094246
cx5
Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(CAG-FCGRT)276Dcr/0
involves: 129X1/SvJ * C57BL/6 * C57BL/6J MGI:4441042


Genotype
MGI:4441043
hm1
Allelic
Composition
Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic
Background
B6.129X1-Fcgrttm1Dcr/DcrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (22 available); any Fcgrt mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system

hematopoietic system




Genotype
MGI:3511521
hm2
Allelic
Composition
Fcgrttm1Dcr/Fcgrttm1Dcr
Genetic
Background
either: 129 or (involves: 129 * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (22 available); any Fcgrt mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• failure of perinatal IgG from mothers to newborns
• levels of maternal IgGs lowered in homozygous pups about 190 fold
• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days
• specific IgG memory response to antigen challenge is significantly reduced

hematopoietic system
• failure of perinatal IgG from mothers to newborns
• levels of maternal IgGs lowered in homozygous pups about 190 fold
• serum half life of IgG1 segnificantly reduced, 1.4 days as opposed to 9 days
• specific IgG memory response to antigen challenge is significantly reduced




Genotype
MGI:5608908
cx3
Allelic
Composition
Albem12Mvw/Albem12Mvw
Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(FCGRT)32Dcr/Tg(FCGRT)32Dcr
Genetic
Background
B6.Cg-Tg(FCGRT)32Dcr Albem12Mvw Fcgrttm1Dcr/MvwJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albem12Mvw mutation (2 available); any Alb mutation (67 available)
Fcgrttm1Dcr mutation (22 available); any Fcgrt mutation (55 available)
Tg(FCGRT)32Dcr mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice lack albumin protein in their blood




Genotype
MGI:6094246
cx4
Allelic
Composition
Fcgrttm1Dcr/Fcgrttm1Dcr
X/Yaa
Genetic
Background
BXSB.129X1-Fcgrttm1Dcr/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (22 available); any Fcgrt mutation (55 available)
Yaa mutation (18 available); any Yaa mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• disruption of Fcgrt does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males




Genotype
MGI:4441042
cx5
Allelic
Composition
Fcgrttm1Dcr/Fcgrttm1Dcr
Tg(CAG-FCGRT)276Dcr/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Dcr mutation (22 available); any Fcgrt mutation (55 available)
Tg(CAG-FCGRT)276Dcr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
N
• IgG levels are normalized





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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory