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Cdh18Tg(GFAP-APOE_i4)1Hol
Transgenic Allele Detail
Nomenclature
Symbol: Cdh18Tg(GFAP-APOE_i4)1Hol
Name: cadherin 18; transgene insertion 1, David M Holtzman
MGI ID: MGI:3057182
Synonyms: GFAP-apoE4 line1, Tg(GFAP-APOE*4)1Hol, Tg(GFAP-APOE4)1Hol
Gene: Cdh18  Location: Chr15:22549108-23474504 bp, + strand  Genetic Position: Chr15, 8.54 cM
Transgene
origin
Strain of Origin:  C57BL/6 or CBA
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Cdh18Tg(GFAP-APOE_i4)1Hol expresses 1 gene
 
Mutation detailsThe transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22) with line 1 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. Line 1 inserted into coordinates 23364633-23373281 (Build GRCm38/mm10) resulting in an 8648 bp deletion. Founder line 1 has a copy number of 10-15. (J:93487)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh18 Mutation:  35 strains or lines available
References
Original:  J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory