About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh18Tg(GFAP-APOE_i4)1Hol
transgene insertion 1, David M Holtzman
MGI:3057182
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Cdh18Tg(GFAP-APOE_i4)1Hol/0 		B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J MGI:3784302
cx2
 		Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Cdh18Tg(GFAP-APOE_i4)1Hol/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784389


Genotype
MGI:3784302
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic
Background		 B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Cdh18Tg(GFAP-APOE_i4)1Hol mutation (1 available); any Cdh18 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes

cellular
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes




Genotype
MGI:3784389
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Cdh18Tg(GFAP-APOE_i4)1Hol mutation (1 available); any Cdh18 mutation (56 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

nervous system
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

cellular
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory