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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdh18Tg(GFAP-APOE_i4)1Hol
transgene insertion 1, David M Holtzman
MGI:3057182
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Cdh18Tg(GFAP-APOE_i4)1Hol/0 		B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J MGI:3784302
cx2
 		Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Cdh18Tg(GFAP-APOE_i4)1Hol/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784389


Genotype
MGI:3784302
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic
Background		 B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (162 available)
Cdh18Tg(GFAP-APOE_i4)1Hol mutation (1 available); any Cdh18 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes

cellular
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes




Genotype
MGI:3784389
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (162 available)
Cdh18Tg(GFAP-APOE_i4)1Hol mutation (1 available); any Cdh18 mutation (56 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

nervous system
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

cellular
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory