Tg(KRT14-Birc5)19Gros
Transgene Detail

Summary

• Symbol: Tg(KRT14-Birc5)19Gros
• Name: transgene insertion 19, Doug Grossman
• MGI ID: MGI:3057126
• Synonyms: K14-Survivin
• Transgene: Tg(KRT14-Birc5)19Gros Location: unknown
• Alliance: Tg(KRT14-Birc5)19Gros page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Birc5)19Gros expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Birc5 (MGI:1203517)

• Mutation details: The transgene contains a 2.1kb sequence of human keratin 14 promoter upstream of the mouse baculoviral IAP repeat-containing 5 (Birc5) gene and a 2.2kb sequence of the human growth hormone and polyadenylation sequence. Transgene expression is specific to epidermal and follicular keratinocytes. Five founder mice were established and line 19 was chosen as the representative line.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:93483 Grossman D, et al., Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest. 2001 Oct;108(7):991-9
• All: 3 reference(s)