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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-Birc5)19Gros
transgene insertion 19, Doug Grossman
MGI:3057126
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(KRT14-Birc5)19Gros/0
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd * C3H * C57BL/6 MGI:3840587
cx2
 		Tg(KRT14-Birc5)19Gros/0
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NCr MGI:3794729
cx3
 		Hrhr/Hrhr
Tg(KRT14-Birc5)19Gros/0 		involves: C3H * C57BL/6 * SKH1 MGI:3794731
tg4
 		Tg(KRT14-Birc5)19Gros/0 involves: C3H * C57BL/6 MGI:3840586


Genotype
MGI:3840587
cx1
Allelic
Composition		 Tg(KRT14-Birc5)19Gros/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Birc5)19Gros mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:81530 )
• fewer transgenic mice develop skin tumors after topical application of DMBA and PMA than Trp53 heterozygote controls
• median time to tumor formation is 25 weeks versus 16 weeks for the Trp53 heterozygote controls
• a lower percentage of mice (71% versus 89%) have tumors 32-weeks after DMBA application compared with controls
• mean tumor burden is 2.29 tumors per mouse compared to 3.0 tumors in controls
• tumor regression is not observed in transgenic mice whereas 10% of tumors in non-transgenic mice regress
• transgenic mice have an increased incidence of atypical papillomas that progress to squamous cell carcinoma

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:81530 )
• fewer transgenic mice develop skin tumors after topical application of DMBA and PMA than Trp53 heterozygote controls
• median time to tumor formation is 25 weeks versus 16 weeks for the Trp53 heterozygote controls
• a lower percentage of mice (71% versus 89%) have tumors 32-weeks after DMBA application compared with controls
• mean tumor burden is 2.29 tumors per mouse compared to 3.0 tumors in controls
• tumor regression is not observed in transgenic mice whereas 10% of tumors in non-transgenic mice regress
• transgenic mice have an increased incidence of atypical papillomas that progress to squamous cell carcinoma




Genotype
MGI:3794729
cx2
Allelic
Composition		 Tg(KRT14-Birc5)19Gros/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Birc5)19Gros mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal skin condition ( J:93483 )
• mice exhibit a reduction in sunburn cells associated with UVB-irradiation compared to wild-type mice and Trp53 heterozygotes but do not exhibit as much of a reduction as in Trp53 homozygotes
decreased sensitivity to skin irradiation ( J:93483 )
• mice exhibit a reduction in skin cell apoptosis associated with UVB-irradiation compared to wild-type mice or Trp53 null mice




Genotype
MGI:3794731
cx3
Allelic
Composition		 Hrhr/Hrhr
Tg(KRT14-Birc5)19Gros/0
Genetic
Background		 involves: C3H * C57BL/6 * SKH1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrhr mutation (17 available); any Hr mutation (84 available)
Tg(KRT14-Birc5)19Gros mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased squamous cell carcinoma incidence ( J:95011 )
• mice exhibit a doubling of the conversion rate of papillomas to squamous cell carcinomas compared to hairless mice
decreased incidence of tumors by UV induction ( J:95011 )
• following chronic exposure to UVB, tumor burden is reduced 1.5-fold compared to in hairless mice

integument
decreased sensitivity to skin irradiation ( J:95011 )
• mice are 2- to 5-fold more resistant to sunburn cell formation than hairless mice following exposure to UVB
• however, skin differentiation is normal




Genotype
MGI:3840586
tg4
Allelic
Composition		 Tg(KRT14-Birc5)19Gros/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Birc5)19Gros mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:81530 )
• less transgenic mice develop skin tumors after topical application of DMBA and PMA than controls
• only 31% of mice develop tumors within 32 weeks of DMBA application compared to 43% of controls
• tumor burden is less with a mean of 1.5 tumors developing per animal compared to 2.0 in controls
• no tumor regression is observed in transgenic mice while 20% of wild-type mice have some tumor regression
• one transgenic mouse developed an aggressive squamous cell carcinoma that was not observed in the wild-type group

integument
abnormal keratinocyte physiology ( J:81530 )
• keratinocytes are resistant to apoptosis caused by topical application of DMBA

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:81530 )
• less transgenic mice develop skin tumors after topical application of DMBA and PMA than controls
• only 31% of mice develop tumors within 32 weeks of DMBA application compared to 43% of controls
• tumor burden is less with a mean of 1.5 tumors developing per animal compared to 2.0 in controls
• no tumor regression is observed in transgenic mice while 20% of wild-type mice have some tumor regression
• one transgenic mouse developed an aggressive squamous cell carcinoma that was not observed in the wild-type group




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory