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Polid
Spontaneous Allele Detail
Nomenclature
Symbol: Polid
Name: polymerase (DNA directed), iota; polymerase iota deficient
MGI ID: MGI:3055735
Synonyms: Poli-, Poli129
Gene: Poli  Location: Chr18:70508680-70530620 bp, - strand  Genetic Position: Chr18, 44.48 cM, cytoband E2
Mutation
origin
Strain of Origin:  129
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA nonsense mutation changes codon 27 from serine (TCG) to an amber stop codon (TAG), and results in a truncated protein lacking any catalytic function. The allele was present in every 129 strain analyzed, including 129P3/J, 129X1/SvJ, 129P1/ReJ and 129P2/Ola. C57BL/6J and BALB/c mice did not contain the mutation. (J:85061, J:228234)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Poli Mutation:  32 strains or lines available
References
Original:  J:85061 McDonald JP, et al., 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J Exp Med. 2003 Aug 18;198(4):635-43
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory