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Spontaneous Allele Detail
Symbol: Polid
Name: polymerase (DNA directed), iota; polymerase iota deficient
MGI ID: MGI:3055735
Synonyms: Poli-, Poli129
Gene: Poli  Location: Chr18:70641751-70663691 bp, - strand  Genetic Position: Chr18, 44.48 cM, cytoband E2
Strain of Origin:  129
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Single point mutation
Mutation detailsA C-to-A nonsense mutation changes codon 27 from serine (TCG) to an amber stop codon (TAG) (SW:Q6R3M4 p.S27*), and results in a truncated protein lacking any catalytic function. The allele was present in every 129 strain analyzed, including 129P3/J, 129X1/SvJ, 129P1/ReJ and 129P2/Ola. C57BL/6J and BALB/c mice did not contain the mutation. (J:85061, J:228234, J:273998)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Poli Mutation:  35 strains or lines available
Original:  J:85061 McDonald JP, et al., 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. J Exp Med. 2003 Aug 18;198(4):635-43
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory