All Phenotypes Poli<d> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Poli^d
polymerase iota deficient
MGI:3055735

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Poli^d/Poli^d	B6.129-Poli^d	MGI:3691211
cx2	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli^d	B6.129-Polh^tm2Fmh Poli^d	MGI:3691209
cx3	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli⁺	B6.129-Polh^tm2Fmh Poli^d	MGI:3691210
cx4	Polh^tm1Crey/Polh^tm1Crey Poli^d/Poli^d	involves: 129P2/OlaHsd * C57BL/6	MGI:3579249
cx5	Poli^d/Poli^d Polk^tm1Hohm/Polk^tm1Hohm	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3623967

Allelic Composition	Poli^d/Poli^d
Genetic Background	B6.129-Poli^d

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Poli^d mutation (3 available); any Poli mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:115000 )

N	• no difference in numbers of epithelial tumors induced by UV-B irradiation compared to wild-type mice

Allelic Composition	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli^d
Genetic Background	B6.129-Polh^tm2Fmh Poli^d

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polh^tm2Fmh mutation (0 available); any Polh mutation (37 available)
Poli^d mutation (3 available); any Poli mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of induced tumors ( J:115000 )

• tumors appear 4 weeks earlier and the average number of tumors is slightly but significantly increased compared to mice wild-type for Poli

• lung tumors, considered to be metastasis from skin tumors, were detected in 3 of 19 mice

• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli

Allelic Composition	Polh^tm2Fmh/Polh^tm2Fmh Poli^d/Poli⁺
Genetic Background	B6.129-Polh^tm2Fmh Poli^d

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of induced tumors ( J:115000 )

• tumors appear 4 weeks earlier than in mice wild-type for Poli

• lung tumors, considered to be metastasis from skin tumors, were detected in 2 of 16 mice

• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli

Allelic Composition	Polh^tm1Crey/Polh^tm1Crey Poli^d/Poli^d
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polh^tm1Crey mutation (2 available); any Polh mutation (37 available)
Poli^d mutation (3 available); any Poli mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

hematopoietic system

abnormal B cell physiology ( J:98037 )

• no B cell anomalies were observed

• Ig sequences from mutant mice PNA ^highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients

Allelic Composition	Poli^d/Poli^d Polk^tm1Hohm/Polk^tm1Hohm
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Poli^d mutation (3 available); any Poli mutation (44 available)
Polk^tm1Hohm mutation (0 available); any Polk mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:105111 )

N	• exhibit normal immunoglobulin gene somatic hypermutation and normal B and T cell populations

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