Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polid mutation
(3 available);
any
Poli mutation
(45 available)
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neoplasm
N |
• no difference in numbers of epithelial tumors induced by UV-B irradiation compared to wild-type mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation
(0 available);
any
Polh mutation
(38 available)
Polid mutation
(3 available);
any
Poli mutation
(45 available)
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neoplasm
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• tumors appear 4 weeks earlier and the average number of tumors is slightly but significantly increased compared to mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 3 of 19 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation
(0 available);
any
Polh mutation
(38 available)
Polid mutation
(3 available);
any
Poli mutation
(45 available)
|
|
|
neoplasm
|
• tumors appear 4 weeks earlier than in mice wild-type for Poli
• lung tumors, considered to be metastasis from skin tumors, were detected in 2 of 16 mice
• mesenchymal skin tumors are detected in some double mutant mice but not in mice wild-type for Poli
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immune system
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• no B cell anomalies were observed
• Ig sequences from mutant mice PNA highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients
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hematopoietic system
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• no B cell anomalies were observed
• Ig sequences from mutant mice PNA highB cells displayed the 85% G/C biased pattern mutation similar to that reported for XP-V patients
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polid mutation
(3 available);
any
Poli mutation
(45 available)
Polktm1Hohm mutation
(0 available);
any
Polk mutation
(65 available)
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immune system
N |
• exhibit normal immunoglobulin gene somatic hypermutation and normal B and T cell populations
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