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Polhtm1Crey
Targeted Allele Detail
Summary
Symbol: Polhtm1Crey
Name: polymerase (DNA directed), eta (RAD 30 related); targeted mutation 1, Claude-Agnes Reynaud
MGI ID: MGI:3577345
Synonyms: Polh-
Gene: Polh  Location: Chr17:46482281-46513567 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband C
Alliance: Polhtm1Crey page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98037
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsLoxP sites were introduced to flank exon 4, which contains the DE polymerase motifs conserved in all Y family polymerases. Cre expression mediated excision of exon 4 in ES cells, resulting in the direct splicing of exons 3-5. The out-of-frame junction would introduce a stop codon and therefore a truncated protein of 102 amino acids. (J:98037)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Polh Mutation:  38 strains or lines available
References
Original:  J:98037 Delbos F, et al., Contribution of DNA polymerase {eta} to immunoglobulin gene hypermutation in the mouse. J Exp Med. 2005 Apr 18;201(8):1191-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory