Birc5^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Birc5^tm1Mak
• Name: baculoviral IAP repeat-containing 5; targeted mutation 1, Tak Mak
• MGI ID: MGI:3046203
• Synonyms: survivin^flox
• Gene: Birc5 Location: Chr11:117740077-117746569 bp, + strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Birc5^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90892
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked exon 2 was inserted via homologous recombination. Cre mediated recombination of this allele results in an early frameshift and translation termination. (J:90892)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Birc5 Mutation: 19 strains or lines available

References

• Original: J:90892 Okada H, et al., Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med. 2004 Feb 2;199(3):399-410
• All: 9 reference(s)