Analysis Tools
normal phenotype
|
• homozygous mice are fertile and display no abnormalities
|
|
Allele Symbol Allele Name Allele ID |
Birc5tm1Mak targeted mutation 1, Tak Mak MGI:3046203 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• homozygous mice are fertile and display no abnormalities
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• more CD25+CD44- double negative cells are in G1 and fewer are in S indicating cell cycle arrest
• no typical telophase cells can be found among the Birc5 deficient cells
|
|
• 37% CD25+CD44-- and 32% of CD25-CD44- double negative cells are apoptotic compared to only 5-7% of cells in littermate controls
|
|
• 37% CD25+CD44-- and 32% of CD25-CD44- double negative cells are apoptotic compared to only 5-7% of cells in littermate controls
|
|
• the thymus lacks the normal cortex-medulla compartmentalization
|
|
• the thymus is much smaller
|
|
• shorter and thicker spindles are seen in mutant CD25+CD44-- and CD25-CD44- double negative cells
• the vast majority of the cells in the thymus appear to be immature thymocytes
|
|
• the average number of thymocytes is about 2% that seen in littermate controls
|
|
• the overall number of DN cells is decreased however these now make up about 95% of the total thymocytes
• CD25+CD44- DN cells make up about 80% of the total DN cells compared to less than 50% in littermate controls
• CD25-CD44- DN cells are reduced to about 4% of the total DN cells compared to less than about 30% in littermate controls
|
|
• 37% CD25+CD44-- and 32% of CD25-CD44- double negative cells are apoptotic compared to only 5-7% of cells in littermate controls
|
|
• the thymus lacks the normal cortex-medulla compartmentalization
|
|
• the thymus is much smaller
|
|
• shorter and thicker spindles are seen in mutant CD25+CD44-- and CD25-CD44- double negative cells
• the vast majority of the cells in the thymus appear to be immature thymocytes
|
|
• the average number of thymocytes is about 2% that seen in littermate controls
|
|
• the overall number of DN cells is decreased however these now make up about 95% of the total thymocytes
• CD25+CD44- DN cells make up about 80% of the total DN cells compared to less than 50% in littermate controls
• CD25-CD44- DN cells are reduced to about 4% of the total DN cells compared to less than about 30% in littermate controls
|
|
• the thymus lacks the normal cortex-medulla compartmentalization
|
|
• the thymus is much smaller
|
|
• the average number of thymocytes is about 2% that seen in littermate controls
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/21/2024 MGI 6.23 |
|
|
|
||