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Targeted Allele Detail
Symbol: Spi1tm1.1Dgt
Name: spleen focus forming virus (SFFV) proviral integration oncogene; targeted mutation 1.1, Daniel G Tenen
MGI ID: MGI:3045207
Synonyms: deltaUREneo, (frt-PGKneo-frt----loxp), PU.1kd/kd, PU.1-knockdown, Sfpi1kd/kd, Sfpi1-knockdown, UREdeltaneo
Gene: Spi1  Location: Chr2:91082390-91115756 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:90331
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Hypomorph)
Mutation:    Intragenic deletion
Mutation detailsSfpi1tm1Dgt mice were crossed with mice carrying Tg(CMV-cre)1Cgn. Activity of the cre recombinase resulted in excision of the upstream regulatory element producing a hypomorphic allele. Mice homozygous for this allele produced only about 20% of wild-type protein product. (J:90331)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spi1 Mutation:  14 strains or lines available
Original:  J:90331 Rosenbauer F, et al., Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet. 2004 Jun;36(6):624-30
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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