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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spi1tm1.1Dgt
targeted mutation 1.1, Daniel G Tenen
MGI:3045207
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spi1tm1.1Dgt/Spi1tm1.1Dgt involves: 129S1/Sv * 129X1/SvJ MGI:3045216


Genotype
MGI:3045216
hm1
Allelic
Composition		 Spi1tm1.1Dgt/Spi1tm1.1Dgt
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm1.1Dgt mutation (0 available); any Spi1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:90331 )
• become rapidly moribund or die between 3 and 8 months of age

neoplasm
increased leukemia incidence ( J:90331 )
• acute myeloid leukemia develops by 3 to 8 months of age

hematopoietic system
abnormal definitive hematopoiesis ( J:90331 )
• periferal WBC counts normal
abnormal erythrocyte cell number ( J:90331 )
• decreased erythroid cells
spleen hyperplasia ( J:90331 )
• hypercellularity and grossly disrupted architecture
• accumulation of immature myeloid cells
• increased numbers of progenitor cells and neutrophils

immune system
spleen hyperplasia ( J:90331 )
• hypercellularity and grossly disrupted architecture
• accumulation of immature myeloid cells
• increased numbers of progenitor cells and neutrophils

liver/biliary system

skeleton
abnormal bone marrow morphology ( J:90331 )
• hypercellularity and grossly disrupted architecture
• accumulation of immature myeloid cells in bone marrow and spleen
• increased numbers of progenitor cells and neutrophils

growth/size/body
enlarged liver ( J:90331 )
enlarged spleen ( J:90331 )
spleen hyperplasia ( J:90331 )
• hypercellularity and grossly disrupted architecture
• accumulation of immature myeloid cells
• increased numbers of progenitor cells and neutrophils

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory