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GckGena348
Chemically induced Allele Detail
Nomenclature
Symbol: GckGena348
Name: glucokinase; Gena348, Harwell
MGI ID: MGI:3044558
Synonyms: GckI366F, Gena348
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Mutation
origin
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsAn A to T transversion is found at position 1096 in exon 9. This results in a missense amino acid change from isoleucine to phenylalanine at position 366. Western blot analysis did not find any significant change in protein expression although glucose phosphorylating activity was significantly impaired. This mutation was generated as part of the Harwell/SB ENU mutagenesis project. (J:90389, J:137483)
Inheritance:    Dominant
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  26 strains or lines available
References
Original:  J:90389 Toye AA, et al., A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. Diabetes. 2004 Jun;53(6):1577-83
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory