All Phenotypes Gck<Gena348> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gck^Gena348
Gena348, Harwell
MGI:3044558

Summary

2 genotypes

Allelic Composition	Gck^Gena348/Gck^Gena348
Genetic Background	involves: BALB/c * C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^Gena348 mutation (2 available); any Gck mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:90389 )

impaired glucose tolerance ( J:90389 )

• blood glucose levels are 280% of wild-type 60 minutes into an intraperitoneal glucose tolerance test

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:90389

Allelic Composition	Gck^Gena348/Gck⁺
Genetic Background	involves: BALB/c * C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gck^Gena348 mutation (2 available); any Gck mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:79719 , J:82809 , J:90389 )

impaired glucose tolerance ( J:90389 )

• blood glucose levels are elevated in heterozygous mice throughout an intraperitoneal glucose tolerance test

growth/size/body

increased body weight ( J:82809 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:90389

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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