About   Help   FAQ
Robo2tm1Mrt
Targeted Allele Detail
Nomenclature
Symbol: Robo2tm1Mrt
Name: roundabout guidance receptor 2; targeted mutation 1, Gail R Martin
MGI ID: MGI:3043127
Synonyms: Robo2-
Gene: Robo2  Location: Chr16:73892306-74411825 bp, - strand  Genetic Position: Chr16, 42.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90324
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3' end of exon 1 including the ATG translational start site and part of the following intron were replaced with an IRES-tauLacZ cassette via homologous recombination. Northern and immunoblot analysis confirmed the absence of RNA and protein in homozygotes. (J:90324)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 31 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Robo2 Mutation:  40 strains or lines available
References
Original:  J:90324 Grieshammer U, et al., SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709-17
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory