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Targeted Allele Detail
Symbol: Robo2tm1Mrt
Name: roundabout guidance receptor 2; targeted mutation 1, Gail R Martin
MGI ID: MGI:3043127
Synonyms: Robo2-
Gene: Robo2  Location: Chr16:73891839-74411825 bp, - strand  Genetic Position: Chr16, 42.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:90324
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 3' end of exon 1 including the ATG translational start site and part of the following intron were replaced with an IRES-tauLacZ cassette via homologous recombination. Northern and immunoblot analysis confirmed the absence of RNA and protein in homozygotes. (J:90324)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 31 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Robo2 Mutation:  2 strains or lines available
Original:  J:90324 Grieshammer U, et al., SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004 May;6(5):709-17
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory