About   Help   FAQ
Chrna5tm1Mdb
Targeted Allele Detail
Nomenclature
Symbol: Chrna5tm1Mdb
Name: cholinergic receptor, nicotinic, alpha polypeptide 5; targeted mutation 1, Mariella De Biasi
MGI ID: MGI:3040917
Synonyms: Alpha5-
Gene: Chrna5  Location: Chr9:54980880-55007779 bp, + strand  Genetic Position: Chr9, 29.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89620
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5, encoding three transmembrane regions and the long intracellular loop, was replaced with a neo cassette. Northern blot confirmed absence of mRNA in mutant brains. (J:89620)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Chrna5 Mutation:  14 strains or lines available
References
Original:  J:89620 Salas R, et al., The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo. Mol Pharmacol. 2003 May;63(5):1059-66
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory