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Chrna5tm1Mdb
Targeted Allele Detail
Nomenclature
Symbol: Chrna5tm1Mdb
Name: cholinergic receptor, nicotinic, alpha polypeptide 5; targeted mutation 1, Mariella De Biasi
MGI ID: MGI:3040917
Synonyms: Alpha5-
Gene: Chrna5  Location: Chr9:54980880-55007779 bp, + strand  Genetic Position: Chr9, 29.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89620
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5, encoding three transmembrane regions and the long intracellular loop, was replaced with a neo cassette. Northern blot confirmed absence of mRNA in mutant brains. (J:89620)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Chrna5 Mutation:  14 strains or lines available
References
Original:  J:89620 Salas R, et al., The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo. Mol Pharmacol. 2003 May;63(5):1059-66
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory