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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chrna5tm1Mdb
targeted mutation 1, Mariella De Biasi
MGI:3040917
Summary 2 genotypes


Genotype
MGI:3042856
hm1
Allelic
Composition		 Chrna5tm1Mdb/Chrna5tm1Mdb
Genetic
Background		 B6.129-Chrna5tm1Mdb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna5tm1Mdb mutation (2 available); any Chrna5 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:89266 )
• less sensitive to nicotine-induced seizures than wild-type controls
• latency time to seizure is significantly shorter than in wild-type

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:89266 )
• less sensitive to nicotine-induced seizures than wild-type controls
• latency time to seizure is significantly shorter than in wild-type




Genotype
MGI:3042858
cx2
Allelic
Composition		 Chrna5tm1Mdb/Chrna5tm1Mdb
Chrnb4tm1Mdb/Chrnb4tm1Mdb
Genetic
Background		 B6.129-Chrnb4tm1Mdb Chrna5tm1Mdb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna5tm1Mdb mutation (2 available); any Chrna5 mutation (40 available)
Chrnb4tm1Mdb mutation (2 available); any Chrnb4 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:89266 )
• less sensitive to nicotine-induced seizures than wild-type controls or single homozygous mutant mice
• latency time to seizure is significantly shorter than in wild-type

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:89266 )
• less sensitive to nicotine-induced seizures than wild-type controls or single homozygous mutant mice
• latency time to seizure is significantly shorter than in wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory