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Chemically induced Allele Detail
Symbol: Ticam1Lps2
Name: toll-like receptor adaptor molecule 1; lipopolysaccharide 2
MGI ID: MGI:2679794
Synonyms: Lps, Lps2, Lps2-, Ticam1-, Ticam1M1Btlr, TRIF-, TrifLps2, Trifm
Gene: Ticam1  Location: Chr17:56576462-56583767 bp, - strand  Genetic Position: Chr17, 29.24 cM
Decreased susceptibility to induced colitis in Ticam1Lps2/Ticam1Lps2 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Intragenic deletion
Mutation detailsENU mutagenesis induced the deletion of a single guanine within codon 708, resulting in a frameshift mutation. The mutation was predicted to replace 24 C-terminal residues with 11 unrelated residues. The mutation was initially detected by screening macrophages for their competence to respond to LPS. (J:84896, J:86521)
Inheritance:    Codominant
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ticam1 Mutation:  37 strains or lines available
Original:  J:86521 Hoebe K, et al., Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9(4):250-5
All:  259 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory