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Wnt11tm1Amc
Targeted Allele Detail
Nomenclature
Symbol: Wnt11tm1Amc
Name: wingless-type MMTV integration site family, member 11; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:2665014
Synonyms: Wnt11-
Gene: Wnt11  Location: Chr7:98484293-98503954 bp, + strand  Genetic Position: Chr7, 53.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83430
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 4 and 5 with a PGK-neo cassette via homologous recombination. RT-PCR analysis of RNA from homozygous mutant animals revealed a truncated transcription product predicted to encode 28 N-terminal amino acids. This mutant protein is expected to be non-functional. (J:83430)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 23 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Wnt11 Mutation:  16 strains or lines available
References
Original:  J:83430 Majumdar A, et al., Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development. 2003 Jul;130(14):3175-85
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory