Phenotypes associated with this allele

• Allele Symbol: Wnt11^tm1Amc
• Allele Name: targeted mutation 1, Andrew P McMahon
• Allele ID: MGI:2665014
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt11^tm1Amc/Wnt11^tm1Amc	involves: 129S1/Sv * 129X1/SvJ	MGI:2665015
cx2	Fzd2^tm1.1Nat/Fzd2^+ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat Wnt11^tm1Amc/Wnt11^+	involves: 129 * C57BL/6	MGI:5444716
cx3	Ret^tm1Cos/Ret^+ Wnt11^tm1Amc/Wnt11^+	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1	MGI:2665016
cx4	Ret^tm1Cos/Ret^+ Wnt11^tm1Amc/Wnt11^tm1Amc	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1	MGI:2665019

Genotype
MGI:2665015

hm1

• Allelic Composition: Wnt11^tm1Amc/Wnt11^tm1Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:83430 )

• mutants surviving to birth die within 2 days post-partum

embryonic lethality during organogenesis, incomplete penetrance ( J:83430 )

• significant number of mutants die by E12.5

renal/urinary system

decreased renal glomerulus number ( J:83430 )

• kidneys of newborn mice have 64% the number of glomeruli found in wild-type

delayed kidney development ( J:83430 )

small kidney ( J:83430 )

renal hypoplasia ( J:83430 )

• kidney hypoplasia

impaired branching involved in ureteric bud morphogenesis ( J:83430 )

• delayed kidney development resulting in abnormal ureteric branching morphogenesis

abnormal ureteric bud tip morphology ( J:83430 )

• at E12.5, there is loss of ureteric tips and some ampullae have abnormal morphology

Genotype
MGI:5444716

cx2

• Allelic Composition: Fzd2^tm1.1Nat/Fzd2⁺; Fzd7^tm1.1Nat/Fzd7^tm1.1Nat; Wnt11^tm1Amc/Wnt11⁺
• Genetic Background: involves: 129 * C57BL/6

cardiovascular system

abnormal heart morphology ( J:189062 )

• 100% of embryos (n=10) display cardiac defects

ventricular septal defect ( J:189062 )

• most defects are VSDs

craniofacial

cleft palate ( J:189062 )

• in 11% of embryos (n=9)

digestive/alimentary system

cleft palate ( J:189062 )

• in 11% of embryos (n=9)

growth/size/body

cleft palate ( J:189062 )

• in 11% of embryos (n=9)

Genotype
MGI:2665016

cx3

• Allelic Composition: Ret^tm1Cos/Ret⁺; Wnt11^tm1Amc/Wnt11⁺
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

renal/urinary system

small kidney ( J:83430 )

• kidneys are 52% the size of wild-type at E18.5

Genotype
MGI:2665019

cx4

• Allelic Composition: Ret^tm1Cos/Ret⁺; Wnt11^tm1Amc/Wnt11^tm1Amc
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

renal/urinary system

small kidney ( J:83430 )

• kidneys are 44% the size of Wnt11-null kidneys and 67% the size of Ret,Wnt11 double heterozygotes

impaired branching involved in ureteric bud morphogenesis ( J:83430 )

• ureteric branching is severely affected at E12.5, much mores so than in Wnt11 null embryos

• kidneys only have 2-4 ureteric buds at E12.5 compared to the normal 7 in wild-type