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Tg(Myh11-cre,-EGFP)2Mik
Transgene Detail
Nomenclature
Symbol: Tg(Myh11-cre,-EGFP)2Mik
Name: transgene insertion 2, Michael I Kotlikoff
MGI ID: MGI:2653286
Synonyms: MH, smMHC-Cre, smMHCCre/eGFP, smMHC/Cre/eGFP, smMHC-Cre-GFPtg, smMHC-Cre-IRES-eGFP, Tg(Myh11-cre/EGFP)1Mik
Transgene: Tg(Myh11-cre,-EGFP)2Mik  Location: unknown  
Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase, Reporter)
Mutation:    Insertion
 
Mutation detailsThe transgene consists of a mouse Myh11 promoter, a cre recombinase gene, an internal ribosome entry site (IRES) and an enhanced GFP gene. 16 kb of mouse Myh11 promoter sequences was used to drive the bicistronic transgene expression in smooth muscle cells. The promoter has also been reported to be active in female germ cells. A low frequency of deletion events are also observed by inheritance from the male germline. (J:81358, J:138838)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myh11     Summary of all recombinase alleles driven by Myh11. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Two transgenic founders, SMCG2 and SMCG3, were created. Transgenic founders were bred to C57BL/6 mice.
References
Original:  J:81358 Xin HB, et al., Smooth muscle expression of Cre recombinase and eGFP in transgenic mice. Physiol Genomics. 2002 Sep 3;10(3):211-5
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory