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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh11-cre,-EGFP)2Mik
transgene insertion 2, Michael I Kotlikoff
MGI:2653286
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mirc32tm1.1Jtm/Mirc32tm1.1Jtm
Tg(Myh11-cre,-EGFP)2Mik/? 		B6.Cg-Mirc32tm1.1Jtm Tg(Myh11-cre,-EGFP)2Mik MGI:5707654
cn2
 		Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Myh11-cre,-EGFP)2Mik/? 		involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 * DBA/2 MGI:5696325
cn3
 		Smarca2tm1Mya/Smarca2+
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5009696
cn4
 		Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5009697
cn5
 		Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5009694
cn6
 		Mylktm1.1Bph/Mylktm1.2Bph
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:5563581
cn7
 		Mylktm1.1Bph/Mylktm1.1Bph
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * C57BL/6N * DBA/2 MGI:5563580
cn8
 		Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * DBA/2 MGI:5550502
cn9
 		Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * DBA/2 MGI:5550501


Genotype
MGI:5707654
cn1
Allelic
Composition		 Mirc32tm1.1Jtm/Mirc32tm1.1Jtm
Tg(Myh11-cre,-EGFP)2Mik/?
Genetic
Background		 B6.Cg-Mirc32tm1.1Jtm Tg(Myh11-cre,-EGFP)2Mik
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc32tm1.1Jtm mutation (1 available); any Mirc32 mutation (3 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
colonic necrosis ( J:214382 )
• observed in DSS treated (+ 2 days recovery) mice

digestive/alimentary system
abnormal intestinal mucosa morphology ( J:214382 )
• lamina propia myofibroblasts within the ulcers of DSS treated (+ 2 days recovery) mice are abnormal
abnormal large intestine crypts of Lieberkuhn morphology ( J:214382 )
• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration
intestinal ulcer ( J:214382 )
• observed in DSS treated (+ 2 days recovery) mice
abnormal colon morphology ( J:214382 )
• colons from DSS treated (+ 2 days recovery) mice remain hemorrhagic and necrotic
• however, phenotype is less severe than in Mirc32tm1.2Jtm mice
colonic necrosis ( J:214382 )
• observed in DSS treated (+ 2 days recovery) mice
impaired intestine regeneration ( J:214382 )
• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration
• pH3+ cells are reduced in number
increased susceptibility to induced colitis ( J:214382 )
• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:214382 )
• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration

immune system
increased susceptibility to induced colitis ( J:214382 )
• DSS treated (+ 2 days recovery) mice exhibit impaired epithelial regeneration




Genotype
MGI:5696325
cn2
Allelic
Composition		 Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Myh11-cre,-EGFP)2Mik/?
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gipc1tm1.1Mhsi mutation (1 available); any Gipc1 mutation (40 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:221554 )
N
• normal arterial tree branching and collateral artery number in the heart and kidney
• normal spinotrapezius arterial tree
• blood flow recovery after hindlimb ischemia is similar to controls at 2 weeks
abnormal systemic artery morphology ( J:221554 )
• trend toward fewer small arteries in heart and kidney
• trend toward larger arterial size in hind limbs




Genotype
MGI:5009696
cn3
Allelic
Composition		 Smarca2tm1Mya/Smarca2+
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.1Pcn mutation (0 available); any Smarca4 mutation (109 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
enlarged cecum ( J:172661 )
• by 4 weeks of age
decreased colon length ( J:172661 )
• the colon is shorter than in wild-type mice
megacolon ( J:172661 )
• by 4 weeks of age
abnormal small intestine morphology ( J:172661 )
• enlarged by 4 weeks of age
decreased small intestine length ( J:172661 )
• mice exhibit short smaller intestine




Genotype
MGI:5009697
cn4
Allelic
Composition		 Smarca2tm1Mya/Smarca2tm1Mya
Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca2tm1Mya mutation (0 available); any Smarca2 mutation (90 available)
Smarca4tm1.1Pcn mutation (0 available); any Smarca4 mutation (109 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:172661 )
• fewer than expected mice are present at P10
• no mice survives beyond 2 weeks

digestive/alimentary system
abnormal digestive system morphology ( J:172661 )
• by 7 to 10 days, all mice develop enlarged gastrointestinal tract unlike control mice
abnormal intestine morphology ( J:172661 )
• mice exhibit dilated intestines filled with air and fecal matter unlike control mice
abnormal intestinal smooth muscle morphology ( J:172661 )
• at E17.5, mice exhibit shorter small intestine compared with control mice
abnormal small intestine morphology ( J:172661 )
• at E17.5, mice exhibit shorter small intestine compared with control mice

muscle
abnormal intestinal smooth muscle morphology ( J:172661 )
• at E17.5, mice exhibit shorter small intestine compared with control mice
abnormal muscle physiology ( J:172661 )
• in neonates, smooth muscle cell apoptosis in the proximal and distal colon is increased compared to in control mice
• however, proliferation of intestinal smooth muscle cell is equivalent to in wild-type mice
impaired smooth muscle contractility ( J:172661 )
• cannulated colonic segments fail to exhibit spontaneous contractile activity compared with control tissue

renal/urinary system
abnormal urinary bladder morphology ( J:172661 )
• by 7 to 10 days, all mice exhibit enlarged urinary bladder unlike control mice




Genotype
MGI:5009694
cn5
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1.1Pcn
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.1Pcn mutation (0 available); any Smarca4 mutation (109 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:172661 )
• fewer than expected mice are present at P10 due to cardiopulmonary defects

digestive/alimentary system
abnormal intestinal smooth muscle morphology ( J:172661 )
• smooth muscle cells are disorganized in the colon compared to in wild-type mice
decreased colon length ( J:172661 )
• in neonates, the colon is shorter than in wild-type mice
abnormal small intestine morphology ( J:172661 )
• mice exhibit enlarged ileum and jejunum compared with wild-type mice
enlarged ileum ( J:172661 )
• mice exhibit enlarged ileum compared with wild-type mice
abnormal jejunum morphology ( J:172661 )
• mice exhibit enlarged jejunum compared with wild-type mice
decreased small intestine length ( J:172661 )
• in neonates, the small intestines are shorter than in wild-type mice

muscle
abnormal intestinal smooth muscle morphology ( J:172661 )
• smooth muscle cells are disorganized in the colon compared to in wild-type mice
abnormal muscle physiology ( J:172661 )
• in neonates, smooth muscle cell apoptosis in the proximal and distal colon is increased compared to in wild-type mice
impaired smooth muscle contractility ( J:172661 )
• in response to KCl or carbachol, colonic rings exhibit impaired contractility compared with wild-type tissue

cardiovascular system
patent ductus arteriosus ( J:172661 )
• in cyanotic mice
ventricular septal defect ( J:172661 )
• in cyanotic mice
dilated heart ( J:172661 )
• in 6 of 18 mice at P0 to P2
abnormal pulmonary circulation ( J:172661 )
• lungs are hyperemic with accumulation of eosinophilic lipoproteinaceous material in the alveolar air space compared to in wild-type mice

respiratory system
abnormal pulmonary circulation ( J:172661 )
• lungs are hyperemic with accumulation of eosinophilic lipoproteinaceous material in the alveolar air space compared to in wild-type mice
primary atelectasis ( J:172661 )
• in cyanotic mice

homeostasis/metabolism
cyanosis ( J:172661 )
• in 6 of 18 mice at P0 to P2

cellular
patent ductus arteriosus ( J:172661 )
• in cyanotic mice




Genotype
MGI:5563581
cn6
Allelic
Composition		 Mylktm1.1Bph/Mylktm1.2Bph
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylktm1.1Bph mutation (0 available); any Mylk mutation (103 available)
Mylktm1.2Bph mutation (0 available); any Mylk mutation (103 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice

mortality/aging
neonatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born
prenatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born

digestive/alimentary system
abnormal small intestine morphology ( J:204964 )
• shorter than in control mice

muscle
impaired smooth muscle contractility ( J:204964 )
• induced by high KCl, carbachol or ET1 in the colon
• however, the L-type calcium channel inhibitor diltiazem blocks contractile responses to high KCl

growth/size/body
growth/size/body region phenotype ( J:204964 )
N
• mice exhibit normal body weight




Genotype
MGI:5563580
cn7
Allelic
Composition		 Mylktm1.1Bph/Mylktm1.1Bph
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mylktm1.1Bph mutation (0 available); any Mylk mutation (103 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Shorter small intestines in mgi:5563563/mgi:5563563 mgi:2653286/0 and mgi:5563563/mgi:5563564 mgi:2653286/0 mice

mortality/aging
neonatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born
prenatal lethality, incomplete penetrance ( J:204964 )
• fewer than expected mice are born

digestive/alimentary system
abnormal small intestine morphology ( J:204964 )
• shorter than in control mice

muscle
impaired smooth muscle contractility ( J:204964 )
• induced by high KCl, carbachol or ET1 in the colon
• however, the L-type calcium channel inhibitor diltiazem blocks contractile responses to high KCl

growth/size/body
growth/size/body region phenotype ( J:204964 )
N
• mice exhibit normal body weight




Genotype
MGI:5550502
cn8
Allelic
Composition		 Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf1tm2Rhc mutation (0 available); any Foxf1 mutation (13 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:203847 )
• no time point given

muscle
abnormal intestinal smooth muscle morphology ( J:203847 )
• slight decreased thickness of the circular smooth muscle layer in the colon
impaired contractility of intestinal smooth muscle ( J:203847 )
• impaired depolarization induced contractility of colonic rings

digestive/alimentary system
abnormal intestinal smooth muscle morphology ( J:203847 )
• slight decreased thickness of the circular smooth muscle layer in the colon




Genotype
MGI:5550501
cn9
Allelic
Composition		 Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf1tm2Rhc mutation (0 available); any Foxf1 mutation (13 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:203847 )
• mice die prior to or immediately after birth

digestive/alimentary system
dilated esophagus ( J:203847 )
• distended esophagus

muscle




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory