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Mtnr1atm1Rep
Targeted Allele Detail
Nomenclature
Symbol: Mtnr1atm1Rep
Name: melatonin receptor 1A; targeted mutation 1, Steven M Reppert
MGI ID: MGI:2450160
Synonyms: MT1-, MT1 KO
Gene: Mtnr1a  Location: Chr8:45069137-45088506 bp, + strand  Genetic Position: Chr8, 24.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41859
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the 5' untranslated region and the first cytoplasmic loop. Autoradiography showed an absence of melatonin binding in sections of homozygous mutant brains, indicating complete functional ablation. (J:41859)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mtnr1a Mutation:  13 strains or lines available
References
Original:  J:41859 Liu C, et al., Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron. 1997 Jul;19(1):91-102
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory