Gdf11^tm1Sjl
Targeted Allele Detail

Nomenclature

• Symbol: Gdf11^tm1Sjl
• Name: growth differentiation factor 11; targeted mutation 1, Sejin Lee
• MGI ID: MGI:2449672
• Synonyms: Gdf11-
• Gene: Gdf11 Location: Chr10:128882295-128891718 bp, - strand Genetic Position: Chr10, 77.18 cM, cytoband D3

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55879
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the majority of the carboxy terminal, which putatively contains the biologically active portion of the protein, was replaced with a neo cassette inserted by homologous recomibation. (J:55879)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	26 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf11 Mutation: 8 strains or lines available

References

• Original: J:55879 McPherron AC, et al., Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat Genet. 1999 Jul;22(3):260-4
• All: 15 reference(s)