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Targeted Allele Detail
Symbol: Gdf11tm1Sjl
Name: growth differentiation factor 11; targeted mutation 1, Sejin Lee
MGI ID: MGI:2449672
Synonyms: Gdf11-
Gene: Gdf11  Location: Chr10:128882295-128891718 bp, - strand  Genetic Position: Chr10, 77.18 cM, cytoband D3
Axial skeleton patterning defects in Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl, Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl Fsttm1Zuk/Fsttm1Zuk, Gdf11tm1Sjl/Gdf11+ and Gdf11tm1Sjl/Gdf11tm1Sjl mice.

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:55879
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding the majority of the carboxy terminal, which putatively contains the biologically active portion of the protein, was replaced with a neo cassette inserted by homologous recomibation. (J:55879)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 48 assay results
In Structures Affected by this Mutation: 26 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf11 Mutation:  8 strains or lines available
Original:  J:55879 McPherron AC, et al., Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat Genet. 1999 Jul;22(3):260-4
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory