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Blnktm1Pjln
Targeted Allele Detail
Nomenclature
Symbol: Blnktm1Pjln
Name: B cell linker; targeted mutation 1, Peter J Nielsen
MGI ID: MGI:2447161
Synonyms: Slp65-, SLP-65-
Gene: Blnk  Location: Chr19:40928927-40994535 bp, - strand  Genetic Position: Chr19, 34.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58740
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 4 and flanking intronic sequences with a neomycin resistance cassette. Northern blot analysis of splenocyte RNA revealed low levels of an aberrantly spliced transcript, however Western blot analysis detected no protein product. (J:58740)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Blnk Mutation:  60 strains or lines available
References
Original:  J:58740 Jumaa H, et al., Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity. 1999 Nov;11(5):547-54
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory