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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Blnktm1Pjln
targeted mutation 1, Peter J Nielsen
MGI:2447161
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Blnktm1Pjln/Blnktm1Pjln involves: BALB/c MGI:2652495
cn2
 		Blnktm1Pjln/Blnktm1Pjln
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug 		involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL MGI:6294907
cx3
 		Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3709377
cx4
 		Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/? 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB MGI:3709379
cx5
 		Blnktm1Pjln/Blnktm1Pjln
Btktm1Wk/Btktm1Wk 		involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:2652543


Genotype
MGI:2652495
hm1
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:80332 )
• 3 out of 45 animals developed solid tumors at 9 - 14 weeks of age

hematopoietic system
enlarged spleen ( J:80332 )
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age
arrested B cell differentiation ( J:58740 )
• arrested B cell development at the pre-B stage
decreased mature B cell number ( J:58740 )
• 5- 10-fold reduction in number of mature B cells in spleen
increased mature B cell number ( J:157575 )
• without an increase in plasma cell differentiation

immune system
enlarged spleen ( J:80332 )
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age
arrested B cell differentiation ( J:58740 )
• arrested B cell development at the pre-B stage
decreased mature B cell number ( J:58740 )
• 5- 10-fold reduction in number of mature B cells in spleen
increased mature B cell number ( J:157575 )
• without an increase in plasma cell differentiation

growth/size/body
enlarged spleen ( J:80332 )
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age




Genotype
MGI:6294907
cn2
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Cd79atm1(cre)Reth/Cd79atm1(cre)Reth
Mzb1tm1.1Rug/Mzb1tm1.1Rug
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Mzb1tm1.1Rug mutation (0 available); any Mzb1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:211639 )
• 2.5-fold reduction in frequency of muHC+ lambda5+ cells in bone marrow
• increase in lambda5+ only bone marrow cells




Genotype
MGI:3709377
cx3
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
Btktm1Gsv mutation (0 available); any Btk mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:94768 )
• B cell development is completely blocked
decreased immature B cell number ( J:94768 )
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
decreased mature B cell number ( J:94768 )
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
decreased IgG3 level ( J:94768 )
• IgG3 severely reduced
decreased IgM level ( J:94768 )
• severely reduced

neoplasm
increased B cell derived lymphoma incidence ( J:94768 )
• increased frequency of pre-B cell lymphomas

hematopoietic system
abnormal B cell differentiation ( J:94768 )
• B cell development is completely blocked
decreased immature B cell number ( J:94768 )
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
decreased mature B cell number ( J:94768 )
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
decreased IgG3 level ( J:94768 )
• IgG3 severely reduced
decreased IgM level ( J:94768 )
• severely reduced




Genotype
MGI:3709379
cx4
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
Btktm1Gsv mutation (0 available); any Btk mutation (22 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
decreased IgG3 level ( J:94768 )
• IgG3 levels remain severely reduced
decreased IgM level ( J:94768 )
• improved or restored

neoplasm
neoplasm ( J:94768 )
N
• tumor suppressor function is restored

hematopoietic system
abnormal B cell differentiation ( J:94768 )
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
decreased IgG3 level ( J:94768 )
• IgG3 levels remain severely reduced
decreased IgM level ( J:94768 )
• improved or restored




Genotype
MGI:2652543
cx5
Allelic
Composition		 Blnktm1Pjln/Blnktm1Pjln
Btktm1Wk/Btktm1Wk
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (76 available)
Btktm1Wk mutation (1 available); any Btk mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:70406 )
• arrested B cell development at the pre-B stage

immune system
arrested B cell differentiation ( J:70406 )
• arrested B cell development at the pre-B stage

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
X-linked agammaglobulinemia DOID:14179 OMIM:300755
 J:70406




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory