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Plcg1tm1Gcrp
Targeted Allele Detail
Nomenclature
Symbol: Plcg1tm1Gcrp
Name: phospholipase C, gamma 1; targeted mutation 1, Graham Carpenter
MGI ID: MGI:2388141
Gene: Plcg1  Location: Chr2:160731310-160775760 bp, + strand  Genetic Position: Chr2, 80.97 cM
Plcg1tm1Rwen/Plcg1tm1Gcrp Tg(Cd4-cre)1Cwi/0 mice develop inflammatory/autoimmune disease

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39281
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsCoding sequence was disrupted by the insertion of a neomycin selection cassette. While normal protein was undetected by Western blot analysis of MEFs derived from homozygous mutant mice, low levels of a shortened peptide containing both amino and carboxy termini was. Calcium mobilization assays showed that the mutant protein responded to serum, but not epidermal growth factor. (J:39281)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcg1 Mutation:  4 strains or lines available
References
Original:  J:39281 Ji QS, et al., Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development [see comments]. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2999-3003
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory