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Targeted Allele Detail
Symbol: Adipoqtm1Chan
Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Lawrence Chan
MGI ID: MGI:2388007
Synonyms: Ad-, Adipo-, ADN-
Gene: Adipoq  Location: Chr16:22965286-22976718 bp, + strand  Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
A basal-like subtype of mammary tumors in Adipoqtm1Chan/Adipoq+ Tg(MMTV-PyVT)634Mul/0 mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:79122
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced by a floxed neo cassette inserted by homologous recombination. Transcript was undetected in adipose tissue by Northern blot analysis of homozygous mutant mice. The lack of immunoreactivity by Western blot analysis using a carboxy terminal antibody indicated an absence of normal and truncated protein. (J:79122)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adipoq Mutation:  30 strains or lines available
Original:  J:79122 Ma K, et al., Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20;277(38):34658-61
All:  86 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory