All Phenotypes Adipoq<tm1Chan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adipoq^tm1Chan
targeted mutation 1, Lawrence Chan
MGI:2388007

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adipoq^tm1Chan/Adipoq^tm1Chan	B6.129-Adipoq^tm1Chan	MGI:3841199
hm2	Adipoq^tm1Chan/Adipoq^tm1Chan	involves: 129S1/Sv * 129X1/SvJ	MGI:3841225
hm3	Adipoq^tm1Chan/Adipoq^tm1Chan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3841221
ht4	Adipoq^tm1Chan/Adipoq⁺	B6.129-Adipoq^tm1Chan	MGI:3841211
cx5	Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0	B6.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul	MGI:3841378
cx6	Adipoq^tm1Chan/Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul/0	either: B6.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul or FVB.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul	MGI:3841377
cx7	Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0	FVB.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul	MGI:3841380

Allelic Composition	Adipoq^tm1Chan/Adipoq^tm1Chan
Genetic Background	B6.129-Adipoq^tm1Chan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79122 )

N	• mice exhibit normal glucose homeostasis and response to a high fat diet

decreased fatty acid beta-oxidation ( J:79122 )

• beta oxidization is decreased 47% in muscle cells and 30% in hepatocytes compared to in wild-type mice

abnormal nitric oxide homeostasis ( J:122020 )

• however, treatment with human recombinant adiponectin restores nitric oxide levels to near normal

• nitric oxide production is decreased 40% compared to in wild-type mice

decreased circulating adiponectin level ( J:122020 )

• adiponectin is virtually undetectable in the plasma unlike in wild-type mice

cellular

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to heterozygous and wild-type endothelium

decreased fatty acid beta-oxidation ( J:79122 )

• beta oxidization is decreased 47% in muscle cells and 30% in hepatocytes compared to in wild-type mice

immune system

increased leukocyte cell number ( J:122020 )

• mice exhibit a 2-fold increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in heterozygous and wild type mice

• leukocyte adhesion to vascular endothelium is increased 5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

cardiovascular system

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to heterozygous and wild-type endothelium

hematopoietic system

increased leukocyte cell number ( J:122020 )

• mice exhibit a 2-fold increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in heterozygous and wild type mice

• leukocyte adhesion to vascular endothelium is increased 5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

Allelic Composition	Adipoq^tm1Chan/Adipoq^tm1Chan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:138678 )

• after 22 weeks

homeostasis/metabolism

abnormal lipid homeostasis ( J:138678 )

• beta-oxidization in skeletal muscles is increased compared to in wild-type mice

muscle

abnormal skeletal muscle fiber morphology ( J:138678 )

• in the tibialis, IIB muscle fiber area is increased compared to in wild-type muscle

Allelic Composition	Adipoq^tm1Chan/Adipoq^tm1Chan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

albuminuria ( J:136297 )

• mice exhibit a 2-fold increase in urine albumin levels compared to in wild-type mice between 1 and 3 months that increased further at 4 months of age

• within 2 months, stereptozotocin-induced diabetic mice exhibit a greater increase in urine albumin levels than in similarly treated wild-type mice that progressively increases at 4 months after diabetes induction

• however, treatment with adiponectin restores normoalbuminuria

fused podocyte foot processes ( J:136297 )

• at 3 months

cellular

oxidative stress ( J:136297 )

• mice exhibit an increase in urine hydrogen peroxide levels compared to in wild-type mice

• stereptozotocin-induced diabetic mice exhibit a greater increase in urine hydrogen peroxide levels than in similarly treated wild-type mice

• however, urine hydrogen peroxide levels are normalize by treatment with adiponectin

homeostasis/metabolism

albuminuria ( J:136297 )

• mice exhibit a 2-fold increase in urine albumin levels compared to in wild-type mice between 1 and 3 months that increased further at 4 months of age

• however, treatment with adiponectin restores normoalbuminuria

Allelic Composition	Adipoq^tm1Chan/Adipoq⁺
Genetic Background	B6.129-Adipoq^tm1Chan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased leukocyte cell number ( J:122020 )

• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in wild type mice

• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

cellular

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

cardiovascular system

increased vascular endothelial cell adhesion ( J:122020 )

• ex vivo, adhesion of aortic endothelium to formyl-Met-Leu-Phe-activated human monocytic cells is increased compared to wild-type endothelium

homeostasis/metabolism

decreased circulating adiponectin level ( J:122020 )

• 58% reduction in total plasma adiponectin levels compared with wild-type mice

hematopoietic system

increased leukocyte cell number ( J:122020 )

• mice exhibit an increase in rolling leukocytes in peri-intestinal venules compared to in wild-type mice that is not as great as in homozygotes

• however, total leukocyte counts are normal

abnormal leukocyte physiology ( J:122020 )

• leukocyte rolling velocity is decreased compared to in wild type mice

• leukocyte adhesion to vascular endothelium is increased 2.5-fold compared in wild-type cells

• however, leukocyte physiology is normalized by treatment with human recombinant adiponectin

Allelic Composition	Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0
Genetic Background	B6.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased metastatic capacity of tumor cells from Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0 mice

neoplasm

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 66 days in females and 114 days in males compared to 73 days and 137 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

increased metastatic potential ( J:147458 )

• tumor cells implanted into nude mice exhibit increased proliferation and are more aggressive than tumor cells isolated from Tg(MMTV-PyVT)634Mul mice

• tumor cells from male mice exhibit increased metastatic capacity in nude mice compared to tumor cells from Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:147458 )

• proliferation of tumor-derived cells is more sensitive to adiponectin-mediated inhibition of cell proliferation than tumor cells from Tg(MMTV-PyVT)634Mul mice

increased tumor growth/size ( J:147458 )

• total wet weight of tumors is 2-fold heavier than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:147458 )

• mice develop tumors with a basal-like subtype

respiratory system

increased lung weight ( J:147458 )

integument

increased mammary gland tumor incidence ( J:147458 )

• mice develop tumors with a basal-like subtype

homeostasis/metabolism

decreased circulating adiponectin level ( J:147458 )

• 4- to 5-fold

growth/size/body

increased lung weight ( J:147458 )

Allelic Composition	Adipoq^tm1Chan/Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul/0
Genetic Background	either: B6.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul or FVB.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:147458 )

• mice die during fetal development

Allelic Composition	Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB.Cg-Adipoq^tm1Chan Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adipoq^tm1Chan mutation (1 available); any Adipoq mutation (40 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

A basal-like subtype of mammary tumors in Adipoq^tm1Chan/Adipoq⁺ Tg(MMTV-PyVT)634Mul/0 mice

neoplasm

increased mammary gland tumor incidence ( J:147458 )

• mice develop mammary gland tumors with a median age of tumor latency of 58 days in females and 115 days in males compared to 66 days and 133.5 days in female and male Tg(MMTV-PyVT)634Mul mice, respectively

• mice develop tumors with a basal-like subtype

increased metastatic potential ( J:147458 )

• tumor cells implanted into nude mice exhibit increased proliferation and are more aggressive than tumor cells isolated from Tg(MMTV-PyVT)634Mul mice

• tumor cells from male mice exhibit increased metastatic capacity in nude mice compared to tumor cells from Tg(MMTV-PyVT)634Mul mice

abnormal tumor morphology ( J:147458 )

• proliferation of tumor-derived cells is more sensitive to adiponectin-mediated inhibition of cell proliferation than tumor cells from Tg(MMTV-PyVT)634Mul mice

increased tumor growth/size ( J:147458 )

• total wet weight of tumors is 2-fold heavier than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:147458 )

• mice develop tumors with a basal-like subtype

respiratory system

increased lung weight ( J:147458 )

integument

increased mammary gland tumor incidence ( J:147458 )

• mice develop tumors with a basal-like subtype

homeostasis/metabolism

decreased circulating adiponectin level ( J:147458 )

• 4- to 5-fold

growth/size/body

increased lung weight ( J:147458 )

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