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Adrb3tm1Jpg
Targeted Allele Detail
Nomenclature
Symbol: Adrb3tm1Jpg
Name: adrenergic receptor, beta 3; targeted mutation 1, Jean-Paul Giacobino
MGI ID: MGI:2387777
Gene: Adrb3  Location: Chr8:27225776-27230845 bp, - strand  Genetic Position: Chr8, 15.94 cM, cytoband A2-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42702
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe first exon of the gene was interrupted by insertion of a neomycin resistance gene driven by a PGK promoter. No transcript could be detected on Northern blots of white and brown adipose tissue from homozygous mutant mice. (J:42702)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adrb3 Mutation:  28 strains or lines available
References
Original:  J:42702 Revelli JP, et al., Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition. J Clin Invest. 1997 Sep 1;100(5):1098-106
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory