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Kif3atm2Gsn
Targeted Allele Detail
Nomenclature
Symbol: Kif3atm2Gsn
Name: kinesin family member 3A; targeted mutation 2, Lawrence SB Goldstein
MGI ID: MGI:2386464
Synonyms: Kif3afl, KIF3Aflox, Kif3afloxed, Kif3atm2Maz
Gene: Kif3a  Location: Chr11:53567379-53601967 bp, + strand  Genetic Position: Chr11, 31.97 cM, cytoband A5-B1
Polycystic kideny disease in Kif3atm1Gsn/Kif3atm2Gsn Tg(Cdh16-cre)91Igr/0 mutant mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63427
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed Tk-Neo cassette was inserted in intron 1 and a third loxP site was inserted downstream of exon 2. Successfully targeted ES cells were transiently transfected with a cre expressing vector which excised the floxed selection cassette. Exon 2 was left flanked by single intronic loxP sites. Western blot analysis of retina and brain tissues showed protein expression to be unaffected by the presence of the loxP sites. This allele was used to generate Kif3atm1Gsn. (J:54575, J:63427, J:131271)
Constructon of the Kif3atm2Gsn allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 34 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kif3a Mutation:  5 strains or lines available
References
Original:  J:63427 Marszalek JR, et al., Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell. 2000 Jul 21;102(2):175-87
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory