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Ikbkgtm1Mak
Targeted Allele Detail
Summary
Symbol: Ikbkgtm1Mak
Name: inhibitor of kappaB kinase gamma; targeted mutation 1, Tak Mak
MGI ID: MGI:2386267
Synonyms: NEMO(-), NEMO/Ikkgamma-deficient
Gene: Ikbkg  Location: ChrX:73436896-73497460 bp, + strand  Genetic Position: ChrX, 38.0 cM
Alliance: Ikbkgtm1Mak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61666
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 1 and 2 with a PGK-neo cassette via homologous recombination resulting in deletion of the first 131 amino acids and a downstream frameshift. Homozygous mutant embryos were detected by PCR genotype analysis up to day E14.5. Western blot analysis of mouse embryonic fibroblasts derived from E12.5 homozygous mutant embryos showed an absence of protein product, thus confirming inactivation of the gene. (J:61666)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkg Mutation:  15 strains or lines available
References
Original:  J:61666 Rudolph D, et al., Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev. 2000 Apr 1;14(7):854-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory