Phenotypes associated with this allele

• Allele Symbol: Ikbkg^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:2386267
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Ikbkg^tm1Mak/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3851597

Genotype
MGI:3851597

ot1

• Allelic Composition: Ikbkg^tm1Mak/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:61666 )

♂ • embryos die between 12.5 and 13.5 due to massive liver hemorrhages

liver/biliary system

liver hemorrhage ( J:61666 )

♂ • E13.5 embryos die due to massive liver hemorrhages

♂ • hemorrhages are first evident at E12.5

increased hepatocyte apoptosis ( J:61666 )

♂ • large number of liver cells are apoptotic at E12.5 and precede or coincide with massive liver bleeding

immune system

increased interleukin-6 secretion ( J:61666 )

♂ • primary embryonic fibroblasts fail to secrete IL-6 upon stimulation with IL-1in the manner of wild-type controls

cellular

increased fibroblast apoptosis ( J:61666 )

♂ • primary embryonic fibroblasts are very sensitive to TNF-mediated apoptosis instead of being resistant as wild-type controls are

increased hepatocyte apoptosis ( J:61666 )

♂ • large number of liver cells are apoptotic at E12.5 and precede or coincide with massive liver bleeding

cardiovascular system

liver hemorrhage ( J:61666 )

♂ • E13.5 embryos die due to massive liver hemorrhages

♂ • hemorrhages are first evident at E12.5