Tg(CAG-Hsp70-1)1Whd
Transgene Detail

Summary

• Symbol: Tg(CAG-Hsp70-1)1Whd
• Name: transgene insertion 1, Wolfgang H Dillmann
• MGI ID: MGI:2385686
• Synonyms: HSP72Tg, Tg(Actb-Hsp70-1)1Whd, Tg(CAG-Hsp70-1)1Whd
• Transgene: Tg(CAG-Hsp70-1)1Whd Location: unknown
• Alliance: Tg(CAG-Hsp70-1)1Whd page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Hsp70-1)1Whd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Hspa1a (24472)

  Hspa1a	(MGI:96244)
  Hspa1b	(MGI:99517)

• Mutation details: The rat Hsp70-1 gene under the control of human CMV immediate early enhancer and chicken beta-actin promoter sequence (including intron 1) was used as the transgene. Overexpression of the rat transgene was verified by Western blot analysis of heart and Northern blot analysis of cardiac and skeletal tissue from transgenic animals. (J:70884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:70884 Marber MS, et al., Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest. 1995 Apr;95(4):1446-56
• All: 17 reference(s)