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Birc5tm1Emc
Targeted Allele Detail
Nomenclature
Symbol: Birc5tm1Emc
Name: baculoviral IAP repeat-containing 5; targeted mutation 1, Edward M Conway
MGI ID: MGI:2384336
Synonyms: survivin-
Gene: Birc5  Location: Chr11:117849251-117855743 bp, + strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78103
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 6.5 kb region containing the entire gene (exons 1-4) was replaced with a lox-P flanked neomycin cassette via homologous recombination. A low percentage of homozygous mutant embryos were observed at 3.5 days post coitum. (J:78103)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Birc5 Mutation:  12 strains or lines available
References
Original:  J:78103 Conway EM, et al., Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. Gastroenterology. 2002 Aug;123(2):619-31
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory