Rorc^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Rorc^tm1Litt
• Name: RAR-related orphan receptor gamma; targeted mutation 1, Dan R Littman
• MGI ID: MGI:2384142
• Synonyms: Rorc-, Rorc^tm1Drl, RORgamma-
• Gene: Rorc Location: Chr3:94280101-94305583 bp, + strand Genetic Position: Chr3, 40.56 cM, cytoband F2
• Alliance: Rorc^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63146
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 200 bp fragment of the gene containing the exon encoding the DNA-binding domain was replaced with a neomycin resistance cassette via homologous recombination. Gene expression was undetectable in various tissues from homozygous mutant animals as determined by Northern blot analysis using a full-length cDNA probe. Western blot analysis did not detect protein expression in thymus of homozygous mutants. (J:63146)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rorc Mutation: 42 strains or lines available

References

• Original: J:63146 Sun Z, et al., Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science. 2000 Jun 30;288(5475):2369-73
• All: 70 reference(s)