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Brca1tm2.1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Brca1tm2.1Cxd
Name: breast cancer 1; targeted mutation 2.1, Chu-Xia Deng
MGI ID: MGI:2182470
Synonyms: Brca1delta11, Brca1deltaexon11, Brcadelta11
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Exencephaly and growth retardation in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70271
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele, lacking exon 11, was generated by crossing mice heterozygous for Brca1tm2Cxd with transgenic mice expressing the cre recombinase gene via the EIIa promoter which is active in germ cells. Northern blot analysis of homozygous mutantembryos indicated an absence of full length transcript. Transcript lacking exon 11 was detected in both wild-type and mutant embryos, though the levels were increased in homozygous mutant embyros. (J:70271)
Phenotypes
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Expression
In Mice Carrying this Mutation: 13 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  43 strains or lines available
References
Original:  J:70271 Xu X, et al., Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71
All:  22 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory