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Targeted Allele Detail
Symbol: Cblbtm1Pngr
Name: Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger
MGI ID: MGI:2180570
Synonyms: Clb-b-
Gene: Cblb  Location: Chr16:52031230-52208047 bp, + strand  Genetic Position: Chr16, 32.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:76896
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin cassette replaced the region encoding a portion of the tyrosine kinase-binding and RING finger domains, corresponding to amino acids 300 through 340 of the encoded protein. Western blot analysis showed an absence of protein expression in lymph nodes and splenocytes from homozygous mice. (J:76896)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Cblb Mutation:  9 strains or lines available
Original:  J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory